Drug-induced inhibition of tubulin polymerization induces mitochondrion-mediated apoptosis in yeast

Cell Cycle. 2011 Sep 15;10(18):3208-9. doi: 10.4161/cc.10.18.16514. Epub 2011 Sep 15.
No abstract available

Publication types

  • Letter

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Apoptosis*
  • Carboxylic Acids / pharmacology
  • Caspases / genetics
  • Caspases / metabolism
  • Gene Deletion
  • Genes, Fungal
  • Growth Inhibitors / pharmacology
  • Indoles / pharmacology
  • Mitochondria / drug effects*
  • Molecular Structure
  • Polymerization*
  • Pyrroles / pharmacology
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Tubulin / metabolism*

Substances

  • 1-(3,4,5-trimethoxybenzyl)-1H-pyrrole-2-carboxylic acid
  • 5-bromo-3-((3,4,5-trimethoxyphenyl)thio)-1H indole
  • Antineoplastic Agents
  • Carboxylic Acids
  • Growth Inhibitors
  • Indoles
  • Pyrroles
  • Saccharomyces cerevisiae Proteins
  • Tubulin
  • Caspases
  • MCA1 protein, S cerevisiae