Abstract
Novel amphiphilic aminoglycosides are shown to inhibit clinically relevant deactivating enzymes, without undergoing significant deactivation themselves.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetyltransferases / antagonists & inhibitors
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Acinetobacter baumannii / drug effects
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Amikacin / metabolism
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Aminoglycosides / chemistry
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Crystallography, X-Ray
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Enzyme Inhibitors / pharmacology*
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Escherichia coli / drug effects
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Kanamycin Kinase / antagonists & inhibitors*
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Klebsiella pneumoniae / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Paromomycin / analogs & derivatives*
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Ribosomes / drug effects
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Ribosomes / metabolism
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Staphylococcus aureus / drug effects
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Enzyme Inhibitors
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Paromomycin
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Amikacin
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Acetyltransferases
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aminoglycoside N(6')-acetyltransferase
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Kanamycin Kinase