Abstract
Ten limonoids, toonacilianins A-J, and two norlimonoids, toonacilianins K and L, together with seven known compounds were isolated from the stems of Toona ciliata var. henryi (Meliaceae). Their structures were elucidated by spectroscopic analysis. Two compounds showed strong cytotoxic activities.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cell Line, Tumor
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Humans
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Leukemia, Myeloid / drug therapy
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Limonins / isolation & purification
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Limonins / pharmacology
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Limonins / therapeutic use*
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Lung Neoplasms / drug therapy
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Meliaceae / chemistry*
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Molecular Structure
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Neoplasms / drug therapy*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Stems / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Limonins
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Plant Extracts
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toonaciliatin A
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toonaciliatin F
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toonaciliatin G