Correlation between serum linezolid concentration and the development of thrombocytopenia

Yoichi Hiraki; Yasuhiro Tsuji; Mikako Hiraike; Nobuhiro Misumi; Kana Matsumoto; Kunihiko Morita; Hidetoshi Kamimura; Yoshiharu Karube

doi:10.3109/00365548.2011.608712

Correlation between serum linezolid concentration and the development of thrombocytopenia

Scand J Infect Dis. 2012 Jan;44(1):60-4. doi: 10.3109/00365548.2011.608712. Epub 2011 Sep 7.

Authors

Yoichi Hiraki¹, Yasuhiro Tsuji, Mikako Hiraike, Nobuhiro Misumi, Kana Matsumoto, Kunihiko Morita, Hidetoshi Kamimura, Yoshiharu Karube

Affiliation

¹ Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto, Kumamoto, Japan. hiraki@kumamoto2.hosp.go.jp

PMID: 21899392
DOI: 10.3109/00365548.2011.608712

Abstract

We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose-response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.

MeSH terms

Acetamides / blood
Acetamides / pharmacokinetics*
Aged
Aged, 80 and over
Anti-Infective Agents / blood
Anti-Infective Agents / pharmacokinetics*
Dose-Response Relationship, Drug
Female
Humans
Linezolid
Male
Middle Aged
Oxazolidinones / blood
Oxazolidinones / pharmacokinetics*
Platelet Count
Pneumonia / drug therapy
Prospective Studies
Thrombocytopenia / epidemiology*

Substances

Acetamides
Anti-Infective Agents
Oxazolidinones
Linezolid