Pyrophosphate-selective fluorescent chemosensor based on 1,8-naphthalimide-DPA-Zn(II) complex and its application for cell imaging

Org Lett. 2011 Oct 7;13(19):5294-7. doi: 10.1021/ol202159x. Epub 2011 Sep 7.

Abstract

A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn(2+) ion and was quenched by addition of PPi.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Animals
  • Cell Line
  • Diphosphates / chemistry*
  • Fluorescent Dyes / chemistry*
  • Mice
  • Models, Molecular
  • Molecular Structure
  • Naphthalimides / chemistry*
  • Picolinic Acids / chemistry*
  • Zinc / chemistry*

Substances

  • 2,2'-dipicolylamine
  • Amines
  • Diphosphates
  • Fluorescent Dyes
  • Naphthalimides
  • Picolinic Acids
  • Zinc