Facing the gem-dialkyl effect in enzyme inhibitor design: preparation of homocycloleucine-based azadipeptide nitriles

Chemistry. 2011 Oct 4;17(41):11419-23. doi: 10.1002/chem.201101350. Epub 2011 Sep 5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cathepsin K / chemical synthesis*
  • Cathepsin K / chemistry
  • Dipeptides / chemical synthesis*
  • Dipeptides / chemistry
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Hydrogen Bonding
  • Leucine / chemistry*
  • Molecular Structure
  • Nitriles / chemistry
  • Nitriles / pharmacology*

Substances

  • Dipeptides
  • Enzyme Inhibitors
  • Nitriles
  • Cathepsin K
  • Leucine