Abstract
Two series of streptocyanine dyes incorporating cyclic peroxide or 4-aminoquinoline moieties are prepared and X-ray diffraction structures for three compounds are determined. All hybrid dyes show good antiplasmodial activity (0.06 to 0.66 μM) and are not or are slightly cytotoxic, except 10a.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoquinolines / chemical synthesis
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Aminoquinolines / chemistry
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Aminoquinolines / pharmacology*
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Animals
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Antimalarials / chemical synthesis
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Carbocyanines / chemical synthesis
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Carbocyanines / chemistry
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Carbocyanines / pharmacology*
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Cell Line, Tumor
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Crystallography, X-Ray
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Humans
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Models, Molecular
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Molecular Structure
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Parasitic Sensitivity Tests
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Peroxides / chemical synthesis
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Peroxides / chemistry
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Peroxides / pharmacology*
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Plasmodium falciparum / drug effects*
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Stereoisomerism
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Vero Cells
Substances
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Aminoquinolines
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Antimalarials
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Carbocyanines
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Peroxides
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4-aminoquinoline