The in vivo anti-plasmodial activity of haliclonacyclamine A, an alkaloid from the marine sponge, Haliclona sp

Nat Prod Res. 2011 Dec;25(20):1923-30. doi: 10.1080/14786419.2010.547858. Epub 2011 Sep 6.

Abstract

The compound haliclonacyclamine A was isolated from the Haliclona sponge at Solomon Islands. It acts as a powerful in vitro and in vivo anti-plasmodial agent against the chloroquine-resistant Plasmodium falciparum strain FCB1and Plasmodium vinckei petteri-infected mice, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Female
  • Haliclona / chemistry*
  • Humans
  • Macrocyclic Compounds / chemistry
  • Macrocyclic Compounds / isolation & purification
  • Macrocyclic Compounds / pharmacology*
  • Macrocyclic Compounds / therapeutic use
  • Magnetic Resonance Spectroscopy
  • Malaria / drug therapy*
  • Melanesia
  • Mice
  • Molecular Structure
  • Piperidines / chemistry
  • Piperidines / isolation & purification
  • Piperidines / pharmacology*
  • Piperidines / therapeutic use
  • Plasmodium / drug effects*
  • Survival Analysis

Substances

  • Macrocyclic Compounds
  • Piperidines
  • haliclonacyclamine A