Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion

Dawei Li; Zhaoqi Yang; Yi Long; Guanjia Zhao; Bei Lv; Shuhui Hiew; Magdeline Tao Tao Ng; Juanjuan Guo; HongKee Tan; Hao Zhang; Weixing Yuan; Haibin Su; Tianhu Li

doi:10.1039/c1cc13158c

Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion

Chem Commun (Camb). 2011 Oct 14;47(38):10695-7. doi: 10.1039/c1cc13158c. Epub 2011 Sep 5.

Authors

Dawei Li¹, Zhaoqi Yang, Yi Long, Guanjia Zhao, Bei Lv, Shuhui Hiew, Magdeline Tao Tao Ng, Juanjuan Guo, HongKee Tan, Hao Zhang, Weixing Yuan, Haibin Su, Tianhu Li

Affiliation

¹ RecDivision of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore.

PMID: 21892494
DOI: 10.1039/c1cc13158c

Abstract

It is demonstrated that the right and left handedness of DNA supercoils can be engineered precisely and readily at the molecular level in vitro through utilization of the invading property of peptide nucleic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA, Circular / chemistry
DNA, Circular / metabolism*
Genetic Engineering
Microscopy, Atomic Force
Peptide Nucleic Acids / chemistry
Peptide Nucleic Acids / metabolism*
Plasmids / chemistry
Plasmids / metabolism

Substances

DNA, Circular
Peptide Nucleic Acids