Abstract
NMR-based analysis of glycans by directly observing hydroxyl protons has been difficult because of their inherently fast exchange with water. We observed hydroxyl proton exchanges in a LewisX-LewisX interaction by using deuterium isotope shifts on (13)C-NMR. This strategy is suitable for analyzing weak interactions by identifying involved protons.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon Isotopes / chemistry
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Deuterium / chemistry
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Hydrogen Bonding
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Lewis X Antigen / analogs & derivatives
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Magnetic Resonance Spectroscopy
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Polysaccharides / chemistry
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Protons*
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Temperature
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Trisaccharides / chemistry*
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Water / chemistry*
Substances
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Carbon Isotopes
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Lewis X Antigen
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Polysaccharides
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Protons
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Trisaccharides
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galactosyl-(1,4)-fucopyranosyl-(1,3)-N-acetylglucosamine
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Water
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Deuterium