Abstract
Several 9H-carbazole derivatives are used for various pharmacological applications. Many of these compounds demonstrated cytotoxic and anticancer activities. In this work, we have investigated the cytotoxic activity of some substituted carbazoles against cancer cell lines (MCF-7, and ISK). The derivative 2a showed the highest inhibitory activity against both cell lines.
MeSH terms
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Adult
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Aged
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Carbazoles / chemical synthesis
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Carbazoles / chemistry
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Carbazoles / pharmacology*
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Carcinoma, Endometrioid / drug therapy*
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Carcinoma, Endometrioid / metabolism
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Carcinoma, Endometrioid / pathology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Endometrial Neoplasms / drug therapy*
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Endometrial Neoplasms / metabolism
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Endometrial Neoplasms / pathology
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Female
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Humans
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Molecular Structure
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Receptors, Estrogen / metabolism*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Carbazoles
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Receptors, Estrogen