Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging

Chem Commun (Camb). 2011 Oct 14;47(38):10635-7. doi: 10.1039/c1cc14019a. Epub 2011 Sep 1.

Abstract

This communication demonstrates that yeast cell wall particles (YCWPs) are a promising class of nature-inspired biocompatible microcarriers for the delivery of amphipathic/lipophilic imaging reporters. When a paramagnetic MRI agent is loaded, the longitudinal relaxivity per particle at 0.5 T is the highest ever reported for Gd-based systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Cell Wall / chemistry*
  • Contrast Media / chemistry*
  • Drug Carriers / chemistry
  • Gadolinium / chemistry
  • Magnetic Resonance Imaging
  • Magnetics
  • Melanoma, Experimental / diagnostic imaging
  • Mice
  • Radionuclide Imaging
  • Rhodamines / chemistry
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / metabolism*

Substances

  • Biocompatible Materials
  • Contrast Media
  • Drug Carriers
  • Rhodamines
  • Gadolinium