Abstract
A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CDC2 Protein Kinase / antagonists & inhibitors
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CDC2 Protein Kinase / chemistry
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Chemistry Techniques, Synthetic
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Enzyme Assays
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Glycogen Synthase Kinase 3 / antagonists & inhibitors
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Glycogen Synthase Kinase 3 / chemistry
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Protein Kinase Inhibitors / analogs & derivatives*
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry
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Stereoisomerism
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Structure-Activity Relationship
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Transition Temperature
Substances
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Imidazoles
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Protein Kinase Inhibitors
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CDC2 Protein Kinase
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Glycogen Synthase Kinase 3