A practical approach to new (5Z) 2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives

Molecules. 2011 Aug 30;16(9):7377-90. doi: 10.3390/molecules16097377.

Abstract

A practical protocol for the preparation of (5Z)-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CDC2 Protein Kinase / antagonists & inhibitors
  • CDC2 Protein Kinase / chemistry
  • Chemistry Techniques, Synthetic
  • Enzyme Assays
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors
  • Glycogen Synthase Kinase 3 / chemistry
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Protein Kinase Inhibitors / analogs & derivatives*
  • Protein Kinase Inhibitors / chemical synthesis
  • Protein Kinase Inhibitors / chemistry
  • Stereoisomerism
  • Structure-Activity Relationship
  • Transition Temperature

Substances

  • Imidazoles
  • Protein Kinase Inhibitors
  • CDC2 Protein Kinase
  • Glycogen Synthase Kinase 3