Oxo-tethered ruthenium(II) complex as a bifunctional catalyst for asymmetric transfer hydrogenation and H2 hydrogenation

J Am Chem Soc. 2011 Sep 28;133(38):14960-3. doi: 10.1021/ja207283t. Epub 2011 Aug 31.

Abstract

Newly developed oxo-tethered Ru amido complexes (R,R)-1 and their HCl adducts (R,R)-2 exhibited excellent catalytic performance for both asymmetric transfer hydrogenation and the hydrogenation of ketonic substrates under neutral conditions without any cocatalysts to give chiral secondary alcohols with high levels of enantioselectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemical synthesis*
  • Alcohols / chemistry
  • Amides / chemistry*
  • Catalysis
  • Hydrogen / chemistry*
  • Hydrogenation
  • Ketones / chemistry
  • Lactones / chemistry
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Alcohols
  • Amides
  • Ketones
  • Lactones
  • Organometallic Compounds
  • Ruthenium
  • Hydrogen