Little has been reported in the literature about self-management strategies of chronic conditions in Asian and Pacific Islanders (APIs). The purpose of this systematic review was to investigate randomized clinical trials (RCTs) of self-management strategies of chronic conditions in APIs. Twenty-one studies were included in the final review, published between 1997 and 2010. Initially, the Jadad Scoring of Quality of Reports of Randomized Clinical Trials (JSQRRC) was used to determine the quality of RCT studies. The researchers then did a systematic review of each of the RCTs based on the JSQRRC criteria. JSQRRC scores ranged from 8 to 12, M = 9.6. Descriptive analysis indicated cognitive behavioral interventions as an effective treatment methodology for APIs. The results underscore the importance of clarifying the methodological components and reporting of RCTs. Interventions appropriate for APIs using disaggregated ethnic groups are essential to determine specific cultural responses to treatments and outcomes.