The incidence of heterogeneous vancomycin-intermediate Staphylococcus aureus correlated with increase of vancomycin MIC

Hongbin Chen; Yudong Liu; Wenjia Sun; Minjun Chen; Hui Wang

doi:10.1016/j.diagmicrobio.2011.06.010

The incidence of heterogeneous vancomycin-intermediate Staphylococcus aureus correlated with increase of vancomycin MIC

Diagn Microbiol Infect Dis. 2011 Nov;71(3):301-3. doi: 10.1016/j.diagmicrobio.2011.06.010.

Authors

Hongbin Chen¹, Yudong Liu, Wenjia Sun, Minjun Chen, Hui Wang

Affiliation

¹ Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, People's Republic of China.

PMID: 21856109
DOI: 10.1016/j.diagmicrobio.2011.06.010

Abstract

A total of 559 methicillin-resistant Staphylococcus aureus isolates were investigated for heterogeneous vancomycin-intermediate S. aureus (hVISA) by population analysis profile area under the curve. Our results suggested that the incidence of hVISA increased rapidly when vancomycin MIC shifted from 1 to 2 μg/mL, and at vancomycin MIC of 2 μg/mL, the incidence of hVISA was nearly 40%.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Humans
Incidence
Methicillin-Resistant Staphylococcus aureus / drug effects*
Methicillin-Resistant Staphylococcus aureus / isolation & purification
Microbial Sensitivity Tests
Staphylococcal Infections / epidemiology
Vancomycin / pharmacology*
Vancomycin Resistance*

Substances

Anti-Bacterial Agents
Vancomycin