Chromatographic analysis of chemical warfare agents

J Chromatogr. 1990 Mar 23;503(2):293-357. doi: 10.1016/s0021-9673(01)81514-4.

Abstract

The usefulness and applications of the particular types of chromatography in the analysis of chemical warfare agents have been reviewed. A major problem in the chromatographic analysis of chemical warfare agents is the collection and preparation of the samples. The importance of this problem differs for the various types of chromatography. Significant differences occur in the way in which samples are collected from air, water, soil, vegetables or animal organisms. The analyses are characterized by the main groups of chemical warfare agents, e.g., organophosphorus, vesicants, irritants, etc. Account has been taken of the relationships between their properties and the possibilities of their chromatographic analysis. The advantages and disadvantages of particular types of chromatography in the analysis of the particular groups and individual agents have been considered. The detectability of particular chemical warfare agents has been assessed, together with the separating efficiency for their mixtures. Examples of applications of chromatographic systems and conditions of chromatographing are summarized in tables. It is concluded that chromatography is a very useful tool in the analysis of chemical warfare agents; GC and TLC have the most advantageous properties, HPLC being slightly inferior.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemical Warfare Agents / analysis*
  • Chromatography, Gas
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Humans

Substances

  • Chemical Warfare Agents