Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14354-9. doi: 10.1073/pnas.1104790108. Epub 2011 Aug 15.

Abstract

Lipid droplets are ubiquitous cellular structures in eukaryotes and are required for lipid metabolism. Little is currently known about plant lipid droplets other than oil bodies. Here, we define dual roles for chloroplast lipid droplets (plastoglobules) in energy and prenylquinone metabolism. The prenylquinones--plastoquinone, plastochromanol-8, phylloquinone (vitamin K(1)), and tocopherol (vitamin E)--are partly stored in plastoglobules. This work shows that NAD(P)H dehydrogenase C1 (NDC1) (At5g08740), a type II NAD(P)H quinone oxidoreductase, associates with plastoglobules. NDC1 reduces a plastoquinone analog in vitro and affects the overall redox state of the total plastoquinone pool in vivo by reducing the plastoquinone reservoir of plastoglobules. Finally, NDC1 is required for normal plastochromanol-8 accumulation and is essential for vitamin K(1) production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / enzymology*
  • Arabidopsis / genetics
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Chloroplasts / enzymology*
  • Chloroplasts / genetics
  • Chromans / metabolism*
  • Gene Expression Regulation, Plant
  • Lipids / chemistry*
  • Luminescent Measurements
  • Mutation / genetics
  • NADH, NADPH Oxidoreductases / genetics
  • NADH, NADPH Oxidoreductases / metabolism*
  • Photosynthesis
  • Plastoquinone / metabolism*
  • Protein Transport
  • Quinone Reductases / metabolism*
  • Quinones / metabolism*
  • Tocopherols / metabolism*
  • Vitamin E / analogs & derivatives*
  • Vitamin E / metabolism
  • Vitamin K 1 / metabolism*

Substances

  • Arabidopsis Proteins
  • Chromans
  • Lipids
  • Quinones
  • Vitamin E
  • plastochromanol 8
  • Vitamin K 1
  • NADH, NADPH Oxidoreductases
  • NDC1 protein, Arabidopsis
  • Quinone Reductases
  • Plastoquinone
  • Tocopherols