Candida albicans adds more weight to iron regulation

Jill R Blankenship; Aaron P Mitchell

doi:10.1016/j.chom.2011.08.001

Candida albicans adds more weight to iron regulation

Cell Host Microbe. 2011 Aug 18;10(2):93-4. doi: 10.1016/j.chom.2011.08.001.

Authors

Jill R Blankenship¹, Aaron P Mitchell

Affiliation

¹ Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

PMID: 21843865
DOI: 10.1016/j.chom.2011.08.001

Abstract

The pathogen Candida albicans can occupy both the bloodstream and gastrointesintal (GI) tract, niches that differ in iron availability. Chen et al. report that a distinct transcription factor, Sef1, alters the conserved fungal iron regulatory paradigm. Sef1 is pivotal for bloodstream infection, but contributes to GI tract colonization as well.

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