Jasisoquinolines A and B, architecturally new isoquinolines, from a marine sponge Jaspis sp

Yasufumi Imae; Kentaro Takada; Shuhei Murayama; Shigeru Okada; Yuji Ise; Shigeki Matsunaga

doi:10.1021/ol201823w

Jasisoquinolines A and B, architecturally new isoquinolines, from a marine sponge Jaspis sp

Org Lett. 2011 Sep 16;13(18):4798-801. doi: 10.1021/ol201823w. Epub 2011 Aug 15.

Authors

Yasufumi Imae¹, Kentaro Takada, Shuhei Murayama, Shigeru Okada, Yuji Ise, Shigeki Matsunaga

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.

PMID: 21842838
DOI: 10.1021/ol201823w

Abstract

Two architecturally new isoquinolines, jasisoquinolines A and B, were isolated from a marine sponge Jaspis sp. as cathepsin B inhibitors. Their structures were determined by a combination of spectroscopic analyses and chemical methods. Both jasisoquinolines A and B inhibit cathepsin B with an IC(50) value of 10 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Isoquinolines / chemistry
Isoquinolines / isolation & purification*
Molecular Conformation
Porifera / chemistry*
Stereoisomerism

Substances

Isoquinolines
jasisoquinoline A
jasisoquinoline B