A novel macrocyclic lactone with insecticidal bioactivity from Streptomyces microflavus neau3

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5145-8. doi: 10.1016/j.bmcl.2011.07.070. Epub 2011 Jul 26.

Abstract

A novel macrocyclic lactone (1) was isolated from the fermentation broth of Streptomycesmicroflavus neau3, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed high acaricidal activity against adult mites (IC(50)=11.1 μg mL(-1)), and nematocidal activity against Caenorhabditis elegans (IC(50)=17.4 μg mL(-1)), especially the acaricidal activity against mite eggs with an IC(50) of 37.1 μg mL(-1), which was relative higher than that of the commercial acaricide and nematocide milbemycins A(3)/A(4).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acaricides / chemistry
  • Acaricides / isolation & purification
  • Acaricides / pharmacology*
  • Animals
  • Antinematodal Agents / chemistry
  • Antinematodal Agents / isolation & purification
  • Antinematodal Agents / pharmacology*
  • Caenorhabditis elegans / drug effects*
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Fermentation
  • Insecticides / chemistry
  • Insecticides / isolation & purification
  • Insecticides / pharmacology
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Macrocyclic Compounds / chemistry
  • Macrocyclic Compounds / isolation & purification
  • Macrocyclic Compounds / pharmacology*
  • Mites / drug effects*
  • Molecular Conformation
  • Stereoisomerism
  • Streptomyces / chemistry
  • Streptomyces / metabolism
  • Structure-Activity Relationship

Substances

  • Acaricides
  • Antinematodal Agents
  • Insecticides
  • Lactones
  • Macrocyclic Compounds