Identification of the metabolites of baicalein in human plasma

J Asian Nat Prod Res. 2011 Sep;13(9):861-8. doi: 10.1080/10286020.2011.599321.

Abstract

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Flavanones / analysis
  • Flavanones / blood
  • Flavanones / chemistry
  • Flavanones / isolation & purification*
  • Flavanones / metabolism
  • Glucuronides / blood
  • Glucuronides / chemistry
  • Glucuronides / isolation & purification*
  • Humans
  • Molecular Structure
  • Scutellaria baicalensis / chemistry*

Substances

  • 7-methoxybaicalein 6-O-glucuronide
  • Flavanones
  • Glucuronides
  • baicalein