Abstract
Polysubstituted pyrroles are regiospecifically synthesized via the copper-catalyzed three-component reaction of α-diazoketones, nitroalkenes, and amines under aerobic conditions. The cascade process involves an N-H insertion of carbene, a copper-catalyzed oxidative dehydrogenation of amine, and a [3 + 2] cycloaddition of azomethine ylide.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkenes / chemistry*
-
Amines / chemistry*
-
Crystallography, X-Ray
-
Ketones / chemistry*
-
Models, Molecular
-
Molecular Structure
-
Nitro Compounds / chemistry*
-
Pyrroles / chemical synthesis*
-
Pyrroles / chemistry
-
Stereoisomerism
Substances
-
Alkenes
-
Amines
-
Ketones
-
Nitro Compounds
-
Pyrroles