Chemo-enzymatic synthesis of a multi-useful chiral building block molecule for the synthesis of medicinal compounds

Molecules. 2011 Aug 9;16(8):6747-57. doi: 10.3390/molecules16086747.

Abstract

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a "low-temperature lipase-catalyzed transesterification" carried out at -40 °C.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Bacterial Proteins / metabolism*
  • Biological Products / chemical synthesis*
  • Catalysis
  • Chemistry, Pharmaceutical*
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Esterification
  • Fungal Proteins / metabolism*
  • Kinetics
  • Lipase / metabolism*
  • Magnetic Resonance Spectroscopy
  • Plant Proteins / metabolism*
  • Stereoisomerism
  • Temperature

Substances

  • Alcohols
  • Bacterial Proteins
  • Biological Products
  • Fungal Proteins
  • Plant Proteins
  • Lipase