Abstract
Four new cembranoids, lobophylins A-D (1-4), and one novel secocembrane, lobophylin E (5) were isolated from a soft coral Lobophytum sp. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods. Among these metabolites, 1-4 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 3,14-ether linkage. In addition, 5 is the first secocembrane possessing two tetrahydrofuran moieties with 3,14- and 4,7-ether linkages.
Keywords:
Lobophytum; secocembrane; soft coral; tetrahydrofuran.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry
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Anthozoa / metabolism
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Anthozoa / microbiology*
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Antineoplastic Agents / analysis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Biological Products / analysis
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Biological Products / chemistry
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Biological Products / metabolism
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Biological Products / pharmacology*
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Cell Line, Tumor
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Diterpenes / analysis
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Diterpenes / chemistry
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Diterpenes / metabolism
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Ethers / chemistry
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Furans / analysis
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Furans / chemistry
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Furans / metabolism
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Furans / pharmacology*
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Hep G2 Cells
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Humans
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K562 Cells
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Molecular Structure
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Oceans and Seas
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Taiwan
Substances
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Antineoplastic Agents
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Biological Products
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Diterpenes
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Ethers
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Furans
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tetrahydrofuran