Cembranoids with 3,14-ether linkage and a secocembrane with bistetrahydrofuran from the Dongsha Atoll soft coral Lobophytum sp

Mar Drugs. 2011;9(7):1243-1253. doi: 10.3390/md9071243. Epub 2011 Jul 12.

Abstract

Four new cembranoids, lobophylins A-D (1-4), and one novel secocembrane, lobophylin E (5) were isolated from a soft coral Lobophytum sp. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods. Among these metabolites, 1-4 are rarely found cembranoids possessing a tetrahydrofuran moiety with a 3,14-ether linkage. In addition, 5 is the first secocembrane possessing two tetrahydrofuran moieties with 3,14- and 4,7-ether linkages.

Keywords: Lobophytum; secocembrane; soft coral; tetrahydrofuran.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry
  • Anthozoa / metabolism
  • Anthozoa / microbiology*
  • Antineoplastic Agents / analysis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Biological Products / analysis
  • Biological Products / chemistry
  • Biological Products / metabolism
  • Biological Products / pharmacology*
  • Cell Line, Tumor
  • Diterpenes / analysis
  • Diterpenes / chemistry
  • Diterpenes / metabolism
  • Diterpenes / pharmacology*
  • Drug Screening Assays, Antitumor
  • Ethers / chemistry
  • Furans / analysis
  • Furans / chemistry
  • Furans / metabolism
  • Furans / pharmacology*
  • Hep G2 Cells
  • Humans
  • K562 Cells
  • Molecular Structure
  • Oceans and Seas
  • Taiwan

Substances

  • Antineoplastic Agents
  • Biological Products
  • Diterpenes
  • Ethers
  • Furans
  • tetrahydrofuran