Abstract
Nine compounds (1-9) were isolated from the fruiting bodies of Stropharia rugosoannulata. Compounds 1-5, 8, and 9 suppressed the formation of osteoclast. Compounds 2 and 5 showed anti-fungal activity, and their MIC were 250 µM and 500 µM respectively. Compounds 2-6 showed inhibitory effects on thapsigargin toxicity.
MeSH terms
-
Agaricales / chemistry*
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology*
-
Biological Products / chemistry
-
Biological Products / pharmacology*
-
Bone Resorption / physiopathology
-
Bone Resorption / prevention & control*
-
Cell Death / drug effects
-
Cell Survival / drug effects
-
Chromatography, Thin Layer
-
Complex Mixtures / chemistry
-
Endoplasmic Reticulum / drug effects
-
Endoplasmic Reticulum / metabolism
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology*
-
Fruiting Bodies, Fungal / chemistry
-
Functional Food / analysis
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Mycoses / drug therapy
-
Mycoses / microbiology
-
Osteoclasts / cytology
-
Osteoclasts / drug effects*
-
Solvents
-
Thapsigargin / chemistry
-
Thapsigargin / pharmacology*
Substances
-
Antifungal Agents
-
Biological Products
-
Complex Mixtures
-
Enzyme Inhibitors
-
Solvents
-
Thapsigargin