Role of β₁-adrenoceptor autoantibodies in the pathogenesis of dilated cardiomyopathy

Abstract

Dilated cardiomyopathy (DCM) is a common cause of heart failure. After the identification of several immune regulatory abnormalities in DCM increasing attention has been focused on autoimmune mechanisms as potential key elements in the pathogenesis of the disease. DCM has appeared to be often related to elevated levels of autoantibodies against cardiac structural or functional proteins. Among several autoantibodies (AABs) which react against cardiac cellular proteins that have been detected in sera from DCM patients, those against β1-adrenoreceptors (β1-ARs) appeared particularly relevant from a pathophysiological point of view. The available experimental and clinical data suggest that in β1-AAB-positive patients with DCM the cardiomyopathy might be a β1-AR-targeted autoimmune disease. This review summarizes the present knowledge about β1-AABs, their role in DCM etiopathogenesis and the therapeutic benefits of β1-AAB removal. Special attention is focused on the possible origin of β1-AABs, their interaction with the β₁-ARs, the prevalence of β1-AABs in patients with DCM and the potential pathophysiologic impact of these AABs in the development and progression of the disease. Attention is also given to the amelioration of β1-AAB cardiotoxicity by β₁-AR antagonists and especially to immunoadsorption (IA) therapy. Responsiveness to IA therapy and its long-term efficiency, as well as post-IA reappearance of β₁-AABs and its impact on patients' outcome are also discussed in detail. Finally the important question of whether the therapeutic results of IA are indeed related to β₁-AAB removal is analyzed on the basis of available data. Overall the review aims to provide an exhaustive overview of the available experimental and clinical data on β₁-AABs in DCM and also a theoretical and practical basis for clinicians who are or intend in future to be engaged in this field.