Abstract
We report the first total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural product.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemistry Techniques, Synthetic
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Cyanobacteria / chemistry*
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Cyclization
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Indole Alkaloids / chemical synthesis*
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Indoles / chemical synthesis
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Indoles / chemistry
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Stereoisomerism
Substances
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Indole Alkaloids
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Indoles
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N-methylwelwitindolinone C isothiocyanate