Objective: To study the secondary metabolites of coastal seaweed endophytic fungi ZJ27.
Methods: The compounds were isolated by chromatographic technique. The structures were identified by comprehensive physic-chemical properties and spectral methods.
Results: Five compounds were isolated and identified as sclerotiorin (1), ochrephilone (2), 6-((3E, 5E)-5,7-dimethyl-2-methylenenona-3,5-dienyl)-2,4-dihydroxy-3-methylbenzaldehyde (3),(2E,4E)-4,6-dimethylocta-2,4-dienoic acid (4), pencolide (5).
Conclusion: 11 g of the compound 1 and 66 mg of the compound 2 were isolated from this fungi indicate that it may develop to be medical source microorganism.