Conjugated oligoelectrolyte-polyhedral oligomeric silsesquioxane loaded pH-responsive nanoparticles for targeted fluorescence imaging of cancer cell nucleus

Dan Ding; Kan-Yi Pu; Kai Li; Bin Liu

doi:10.1039/c1cc13237g

Conjugated oligoelectrolyte-polyhedral oligomeric silsesquioxane loaded pH-responsive nanoparticles for targeted fluorescence imaging of cancer cell nucleus

Chem Commun (Camb). 2011 Sep 21;47(35):9837-9. doi: 10.1039/c1cc13237g. Epub 2011 Aug 2.

Authors

Dan Ding¹, Kan-Yi Pu, Kai Li, Bin Liu

Affiliation

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore.

PMID: 21808781
DOI: 10.1039/c1cc13237g

Abstract

We report conjugated oligoelectrolyte-polyhedral oligomeric silsesquioxane (COE-POSS) loaded and pH-triggered chitosan/poly(ethylene glycol) nanoparticles with folic acid functionalization for targeted imaging of cancer cell nucleus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Breast Neoplasms / pathology*
Cell Line, Tumor
Cell Nucleus / metabolism*
Chitosan / chemistry*
Female
Fluorescent Dyes / chemistry
Humans
Hydrogen-Ion Concentration
Mice
Molecular Imaging / methods*
NIH 3T3 Cells
Nanoparticles / chemistry*
Organosilicon Compounds / chemistry*
Polyethylene Glycols / chemistry*
Spectrometry, Fluorescence

Substances

Fluorescent Dyes
Organosilicon Compounds
Polyethylene Glycols
Chitosan