Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula

J Nat Prod. 2011 Aug 26;74(8):1686-91. doi: 10.1021/np2005083. Epub 2011 Aug 1.

Abstract

Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, respectively).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Amino Acids / chemistry
  • Animals
  • Cyanobacteria / chemistry*
  • Depsipeptides / chemistry
  • Depsipeptides / isolation & purification*
  • Depsipeptides / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Stereoisomerism
  • Transcription Factor AP-1 / drug effects*

Substances

  • Amino Acids
  • Depsipeptides
  • Transcription Factor AP-1
  • grassypeptolide F
  • grassypeptolide G