Abstract
A study identifies mechanisms responsible for the inability to form new myelin after neonatal hypoxia. It identifies Axin2 as a potential therapeutic target for reversing the ‘differentiation block’ of oligodendrocyte-lineage cells.
MeSH terms
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Animals
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Axin Protein
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Cell Differentiation
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Cytoskeletal Proteins / physiology*
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Cytoskeletal Proteins / therapeutic use
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Demyelinating Diseases* / enzymology
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Demyelinating Diseases* / metabolism
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Demyelinating Diseases* / therapy
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Humans
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Models, Biological
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Oligodendroglia / physiology
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Tankyrases / antagonists & inhibitors*
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Wnt Proteins / metabolism
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beta Catenin / metabolism
Substances
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AXIN2 protein, human
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Axin Protein
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Cytoskeletal Proteins
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Wnt Proteins
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beta Catenin
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Tankyrases