Anti-TANKyrase weapons promote myelination

Nat Neurosci. 2011 Jul 26;14(8):945-7. doi: 10.1038/nn.2885.

Abstract

A study identifies mechanisms responsible for the inability to form new myelin after neonatal hypoxia. It identifies Axin2 as a potential therapeutic target for reversing the ‘differentiation block’ of oligodendrocyte-lineage cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axin Protein
  • Cell Differentiation
  • Cytoskeletal Proteins / physiology*
  • Cytoskeletal Proteins / therapeutic use
  • Demyelinating Diseases* / enzymology
  • Demyelinating Diseases* / metabolism
  • Demyelinating Diseases* / therapy
  • Humans
  • Models, Biological
  • Oligodendroglia / physiology
  • Tankyrases / antagonists & inhibitors*
  • Wnt Proteins / metabolism
  • beta Catenin / metabolism

Substances

  • AXIN2 protein, human
  • Axin Protein
  • Cytoskeletal Proteins
  • Wnt Proteins
  • beta Catenin
  • Tankyrases