Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Biomaterials. 2011 Nov;32(31):7924-31. doi: 10.1016/j.biomaterials.2011.07.017. Epub 2011 Jul 23.

Abstract

The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Chromatography, High Pressure Liquid
  • Cryoelectron Microscopy
  • Docetaxel
  • Drug Delivery Systems*
  • Membrane Fusion* / drug effects
  • Mice
  • Nanoparticles / ultrastructure
  • Particle Size
  • Spectroscopy, Near-Infrared
  • Taxoids / administration & dosage
  • Taxoids / pharmacology
  • Taxoids / therapeutic use
  • Treatment Outcome
  • Unilamellar Liposomes / chemistry*

Substances

  • Antineoplastic Agents
  • Taxoids
  • Unilamellar Liposomes
  • Docetaxel