Carbofuran in water: Subchronic toxicity to rats

Dragica V Brkić; Slavoljub Lj Vitorović; Slavica M Gašić; Neško K Nešković

doi:10.1016/j.etap.2007.11.002

Carbofuran in water: Subchronic toxicity to rats

Environ Toxicol Pharmacol. 2008 May;25(3):334-41. doi: 10.1016/j.etap.2007.11.002. Epub 2007 Nov 17.

Authors

Dragica V Brkić¹, Slavoljub Lj Vitorović, Slavica M Gašić, Neško K Nešković

Affiliation

¹ Institute of Pesticides and Environmental Protection, Banatska 31-b, P.O. Box 163, 11080 Belgrade, Serbia.

PMID: 21783871
DOI: 10.1016/j.etap.2007.11.002

Abstract

Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.