Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels

Gohar Fakhfouri; Reza Rahimian; Saeed Hashemi; Mohammad Reza Rasouli; Arash Bahremand; Shahram Ejtemaei Mehr; Mohammad Reza Khorramizadeh; Ahmad Reza Dehpour

doi:10.1111/j.1472-8206.2011.00928.x

Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels

Fundam Clin Pharmacol. 2012 Apr;26(2):190-3. doi: 10.1111/j.1472-8206.2011.00928.x.

Authors

Gohar Fakhfouri¹, Reza Rahimian, Saeed Hashemi, Mohammad Reza Rasouli, Arash Bahremand, Shahram Ejtemaei Mehr, Mohammad Reza Khorramizadeh, Ahmad Reza Dehpour

Affiliation

¹ Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 21777273
DOI: 10.1111/j.1472-8206.2011.00928.x

Abstract

The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.

MeSH terms

Animals
Colitis / drug therapy*
Colitis / physiopathology
Cyclic GMP / metabolism*
Disease Models, Animal
Glyburide / pharmacology
KATP Channels / metabolism*
Male
Phosphodiesterase 5 Inhibitors / pharmacology
Piperazines / pharmacology*
Purines / pharmacology
Rats
Rats, Sprague-Dawley
Sildenafil Citrate
Sulfones / pharmacology*
Trinitrobenzenesulfonic Acid / toxicity

Substances

KATP Channels
Phosphodiesterase 5 Inhibitors
Piperazines
Purines
Sulfones
Trinitrobenzenesulfonic Acid
Sildenafil Citrate
Cyclic GMP
Glyburide