A facile preparation of trisubstituted amino-furan and -thiophene derivatives

Org Biomol Chem. 2011 Sep 7;9(17):6055-65. doi: 10.1039/c1ob05216k. Epub 2011 Jul 20.

Abstract

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.