Copper-mediated trifluoromethylation of arylboronic acids by trifluoromethyl sulfonium salts

Chem Commun (Camb). 2011 Sep 7;47(33):9516-8. doi: 10.1039/c1cc13460d. Epub 2011 Jul 19.

Abstract

The ligand-free trifluoromethylation of arylboronic acids with a [Ph(2)SCF(3)](+)[OTf](-)/Cu(0) system has been carefully investigated. Aryl-, alkenyl- and heteroarylboronic acids with a variety of functional groups were suitable substrates for this reaction. It is suggested that a CuCF(3) species is formed under the reaction conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Salts / chemistry
  • Sulfonium Compounds / chemistry*

Substances

  • Boronic Acids
  • Salts
  • Sulfonium Compounds
  • Copper