Abstract
We report 9 ciprofloxacin-resistant Salmonella enterica serotype Typhi isolates submitted to the US National Antimicrobial Resistance Monitoring System during 1999-2008. The first 2 had indistinguishable pulsed-field gel electrophoresis patterns and identical gyrA and parC mutations. Eight of the 9 patients had traveled to India within 30 days before illness onset.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adolescent
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Adult
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Anti-Bacterial Agents / pharmacology*
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Child
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Child, Preschool
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Ciprofloxacin / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial / genetics
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Female
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Gene Expression Regulation, Bacterial / drug effects
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Humans
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Infant
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation / genetics
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Salmonella typhi / drug effects*
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Salmonella typhi / genetics
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Salmonella typhi / isolation & purification
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Typhoid Fever / epidemiology*
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Typhoid Fever / microbiology*
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United States / epidemiology
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Young Adult
Substances
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Anti-Bacterial Agents
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Ciprofloxacin
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DNA Topoisomerase IV
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DNA Gyrase