Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008

Emerg Infect Dis. 2011 Jun;17(6):1095-8. doi: 10.3201/eid/1706.100594.

Abstract

We report 9 ciprofloxacin-resistant Salmonella enterica serotype Typhi isolates submitted to the US National Antimicrobial Resistance Monitoring System during 1999-2008. The first 2 had indistinguishable pulsed-field gel electrophoresis patterns and identical gyrA and parC mutations. Eight of the 9 patients had traveled to India within 30 days before illness onset.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Ciprofloxacin / pharmacology*
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / genetics
  • Drug Resistance, Bacterial / genetics
  • Female
  • Gene Expression Regulation, Bacterial / drug effects
  • Humans
  • Infant
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mutation / genetics
  • Salmonella typhi / drug effects*
  • Salmonella typhi / genetics
  • Salmonella typhi / isolation & purification
  • Typhoid Fever / epidemiology*
  • Typhoid Fever / microbiology*
  • United States / epidemiology
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin
  • DNA Topoisomerase IV
  • DNA Gyrase