Abstract
We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial* / genetics
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Gene Expression Regulation, Bacterial / drug effects
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Genes, Bacterial / genetics
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Haplotypes
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Humans
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Microbial Sensitivity Tests
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Mutation / genetics
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Phenotype*
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Quinolones / pharmacology*
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Salmonella typhi / drug effects*
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Salmonella typhi / genetics
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Typhoid Fever / microbiology*
Substances
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Anti-Bacterial Agents
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Quinolones