Salivary alpha-amylase activity: a possible indicator of pain-induced stress in orthodontic patients

Pain Med. 2011 Aug;12(8):1162-6. doi: 10.1111/j.1526-4637.2011.01185.x. Epub 2011 Jul 12.

Abstract

Introduction: Pain, a common experience reported by orthodontic patients, has its intensity assessed with the help of subjective scales, which have a limited and disputable value. Such unpleasant experience, which may raise stress levels, is reflected by an increase in the salivary concentration of alpha-amylase.

Objective: Assess the correlation between the salivary levels of alpha-amylase and pain intensity reported by patients during orthodontic treatment.

Patients: Twenty male patients (11-37 years of age) were assessed daily, before treatment, after bracket bonding, and after initial arch wire insertion.

Design: Saliva was sampled for alpha-amylase analysis, and pain intensity was measured with the visual analog scale.

Results: There was no correlation between alpha-amylase concentrations in the saliva and pain intensity, although the patients had a significant and progressive increase of alpha-amylase levels during the assessment period.

Conclusions: The findings may reflect the psychological stress caused by the presence and activation of the fixed appliance.

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers / metabolism*
  • Child
  • Humans
  • Male
  • Orthodontic Appliances / adverse effects*
  • Pain Measurement*
  • Salivary alpha-Amylases / metabolism*
  • Stress, Psychological*
  • Young Adult

Substances

  • Biomarkers
  • Salivary alpha-Amylases