Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule

Mar Drugs. 2011;9(6):994-1006. doi: 10.3390/md9060994. Epub 2011 Jun 9.

Abstract

Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.

Keywords: Sarcophyton crassocaule; anti-inflammatory activity; cytotoxic activity; soft coral.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Cell Line, Tumor
  • Cyclooxygenase 2 / metabolism
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Drug Screening Assays, Antitumor / methods
  • Humans
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Nitric Oxide Synthase Type II / antagonists & inhibitors
  • Nitric Oxide Synthase Type II / metabolism
  • Structure-Activity Relationship
  • Taiwan

Substances

  • Anti-Inflammatory Agents
  • Diterpenes
  • Lipopolysaccharides
  • cembrane
  • Nitric Oxide Synthase Type II
  • Cyclooxygenase 2