Comparison of modulated electron radiotherapy to conventional electron boost irradiation and volumetric modulated photon arc therapy for treatment of tumour bed boost in breast cancer

Abstract

Background and purpose: To compare few leaf electron collimator (FLEC)-based modulated electron radiotherapy (MERT) to conventional direct electron (DE) and volumetric modulated photon arc therapy (VMAT) for the treatment of tumour bed boost in breast cancer.

Materials and methods: Fourteen patients with breast cancer treated by lumpectomy and requiring post-operative whole breast radiotherapy with tumour bed boost were planned retrospectively using conventional DE, VMAT and FLEC-based MERT. The planning goal was to deliver 10Gy to at least 95% of the tumour bed volume. Dosimetry parameters for all techniques were compared.

Results: Dose evaluation volume (DEV) coverage and homogeneity were best for MERT (D(98)=9.77Gy, D(2)=11.03Gy) followed by VMAT (D(98)=9.56Gy, D(2)=11.07Gy) and DE (D(98)=9.81Gy, D(2)=11.52Gy). Relative to the DE plans, the MERT plans predicted a reduction of 35% in mean breast dose (p<0.05), 54% in mean lung dose (p<0.05) and 46% in mean body dose (p<0.05). Relative to the VMAT plans, the MERT plans predicted a reduction of 24%, 36% and 39% in mean breast dose, heart dose and body dose, respectively (p<0.05).

Conclusions: MERT plans were a considerable improvement in dosimetry over DE boost plans. There was a dosimetric advantage in using MERT over VMAT for increased DEV conformity and low-dose sparing of healthy tissue including the integral dose; however, the cost is often an increase in the ipsilateral lung high-dose volume.