The aim of this research was to analyze the Secondary School Managers' response to the availability of a physical and psychological space at school to work on drug addiction prevention. A semi-structured questionnaire was applied to a sample of 15 high school managers in the Argentinean Education System (public and private schools) in Buenos Aires city and in the Province of Buenos Aires. A qualitative survey was carried out within the theoretical framework of International Health Regulations, School Management, Social Psychology and formal school regulations. These managers assume that the prevention of drug addiction should be addressed at school, with the support of other institutions and experts. The main objective should be to promote professional training in health, psychology and group dynamics and to create a warm environment at school, based on empathy, understanding and tolerance to strengthen the bond with the students.