Breast cancer classification based on advanced multi dimensional fuzzy neural network

J Med Syst. 2012 Oct;36(5):2713-20. doi: 10.1007/s10916-011-9747-5. Epub 2011 Jul 1.

Abstract

Breast cancer is the cause of the most common cancer death in women. Early detection of the breast cancer is an effective method to reduce mortality. Fuzzy Neural Networks (FNN) comprises an integration of the merits of neural and fuzzy approaches, enabling one to build more intelligent decision-making systems. But increasing the number of inputs causes exponential growth in the number of parameters in Fuzzy Neural Networks (FNN) and computational complexity increases accordingly. This phenomenon is named as "curse of dimensionality". The Hierarchical Fuzzy Neural Network (HFNN) and the Fuzzy Gaussian Potential Neural Network (FGPNN) are utilized to deal this problem. In this study, the HFNN and FGPNN by using new training algorithm, are applied to the Wisconsin Breast Cancer Database to classify breast cancer into two groups; benign and malignant lesions. The HFNN consists of hierarchically connected low-dimensional fuzzy neural networks. It can use fewer rules and parameters to model nonlinear system. Moreover, the FGPNN consists of Gaussian Potential Function (GPF) used in the antecedent as the membership function. When the number of inputs increases in FGPNN, the number of fuzzy rules does not increase. The performance of HFNN and FGPNN are evaluated and compared with FNN. Simulation results show the effectiveness of these methods even with less rules and parameters in performance result. These methods maintain the accuracy of original fuzzy neural system and have high interpretability by human in diagnosis of breast cancer.

MeSH terms

  • Breast Neoplasms / classification*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / diagnostic imaging
  • Cell Adhesion
  • Cell Shape
  • Cell Size
  • Female
  • Fuzzy Logic*
  • Humans
  • Neural Networks, Computer*
  • Radiography