Immunogenicity of conjugate meningococcus C vaccine in pediatric solid organ transplant recipients

Vaccine. 2011 Aug 26;29(37):6163-6. doi: 10.1016/j.vaccine.2011.06.033. Epub 2011 Jun 28.

Abstract

The present study was aimed to evaluate the immunogenicity of a single dose of conjugate Meningococcus C (Men C) vaccine by analyzing the serum bactericidal antibody (SBA) titers in 10 pediatric solid organ transplant (SOT) patients. Four patients showed a delayed immune response after 1 month, but all patients demonstrated an increase of SBA titers after vaccination. A significant decrease of SBA titers was seen after 6 months. However, all patients maintained protective SBA titers (≥1:8) despite rapidly waning titers. For patients with significantly decreasing titers, a booster dose may be discussed with close monitoring of SBA titers over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / blood*
  • Child
  • Female
  • Humans
  • Immunization, Secondary
  • Male
  • Meningitis, Meningococcal / immunology
  • Meningitis, Meningococcal / prevention & control
  • Meningococcal Vaccines* / administration & dosage
  • Meningococcal Vaccines* / adverse effects
  • Meningococcal Vaccines* / immunology
  • Meningococcal Vaccines* / therapeutic use
  • Neisseria meningitidis, Serogroup C / immunology
  • Organ Transplantation*
  • Serum Bactericidal Antibody Assay
  • Vaccination
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / immunology

Substances

  • Antibodies, Bacterial
  • Meningococcal Vaccines
  • Vaccines, Conjugate