Abstract
Immunization of mice with inactivated polio vaccine (IPV) with concurrent dosing of poliovirus antiviral V-073 showed no detrimental impact on the elicitation of serum-neutralizing antibodies. A strategy involving coadministration of antiviral V-073 and IPV can be considered for the management of poliovirus incidents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Neutralizing / blood*
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Antibodies, Viral / blood*
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Antiviral Agents / administration & dosage*
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Mice
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Poliovirus Vaccine, Inactivated / administration & dosage*
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Poliovirus Vaccine, Inactivated / immunology*
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Antiviral Agents
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Poliovirus Vaccine, Inactivated