MRSA infections continue to be a serious and formidable challenge to health care providers and their prevalence is increasing exponentially. In the past, MRSA infections were observed only in hospitalized patients whereas now they are encountered in the outpatient setting. Understanding the pattern of the widespread distribution of MRSA as well as the factors associated with its spread are paramount to its recognition and eradication. The current state of MRSA transmission, control and management is reviewed.