Lymphocyte signaling converges on microtubules

Alexander Babich; Janis K Burkhardt

doi:10.1016/j.immuni.2011.06.004

Lymphocyte signaling converges on microtubules

Immunity. 2011 Jun 24;34(6):825-7. doi: 10.1016/j.immuni.2011.06.004.

Authors

Alexander Babich¹, Janis K Burkhardt

Affiliation

¹ Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

PMID: 21703536
DOI: 10.1016/j.immuni.2011.06.004

Abstract

Movement of immunoreceptor microclusters tunes lymphocyte activation, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Schnyder et al. (2011) and Hashimoto-Tane et al. (2011) show that cytoplasmic dynein drives microcluster centralization along microtubules.

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