Abstract
Paclitaxel and sorafenib loaded albumin nanoparticles (PTX-SRF-BSA-NPs) were prepared and studied here to avoid the toxicities from the excipients in the Taxol® and explore the effect of such combination on the antitumour efficacy and toxicity. PTX-BSA-NPs and so on were used as controls. The particle size, zeta potential, encapsulation efficiency and morphology were evaluated. Less than 70% of each drug released within 24 h. PTX and SRF existed as molecular or amorphous form in the PTX-SRF-BSA-NPs. The particle size did not change much after 2-month storage in freeze-dried form or 24 h in suspension. The treatment with PTX-SRF-BSA-NPs (7.5 mg kg(-1) PTX + 7.5 mg kg(-1) SRF) exhibited lower myelosuppression than PTX-BSA-NPs (15 mg kg(-1) PTX) while it remained or increased the antitumour effect in mice tumour models. Compared with the solution containing the same level of PTX and SRF, PTX-SRF-BSA-NPs demonstrated significantly lower haemolysis and myelosuppression effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use
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Benzenesulfonates / administration & dosage*
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Benzenesulfonates / adverse effects
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Benzenesulfonates / therapeutic use
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Cattle
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Cell Line, Tumor
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Drug Carriers / chemistry*
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Female
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Hemolysis / drug effects
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Humans
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Nude
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Nanoparticles / chemistry*
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Nanoparticles / ultrastructure
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Neoplasms / drug therapy
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Niacinamide / analogs & derivatives
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Paclitaxel / administration & dosage*
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Paclitaxel / adverse effects
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Paclitaxel / therapeutic use
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Phenylurea Compounds
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Pyridines / administration & dosage*
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Pyridines / adverse effects
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Pyridines / therapeutic use
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Rats
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Rats, Sprague-Dawley
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Serum Albumin, Bovine / chemistry*
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Sorafenib
Substances
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Antineoplastic Agents
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Benzenesulfonates
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Drug Carriers
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Phenylurea Compounds
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Pyridines
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Niacinamide
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Serum Albumin, Bovine
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Sorafenib
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Paclitaxel