Abstract
Bioassay-guided isolation of the EtOAc extract of a marine Bacillus sp., cultured in modified Bennett's broth medium, yielded four new antimicrobial fatty acids, named ieodomycins A-D. The planar structures of these new compounds were determined by extensive 1D and 2D NMR and HRESIMS spectroscopic data analysis. Their absolute configurations were elucidated by modified Mosher's method and literature data review. All four new compounds demonstrated antimicrobial activities in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology*
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Bacillus / chemistry*
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Bacillus subtilis / drug effects
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Escherichia coli / drug effects
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification*
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Fatty Acids, Unsaturated / pharmacology*
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Humans
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Saccharomyces cerevisiae / drug effects
Substances
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Anti-Infective Agents
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Fatty Acids, Unsaturated
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Ieodomycin A